Life-threatening infections on the rise due to drug-resistant bacteria, new WHO report reveals

By World Organization for Development Last updated Dec 19, 2022

Moreover, the high levels of resistance to treatment are reported in bacteria frequently causing bloodstream infections in hospitals the Global Antimicrobial Resistance and Use Surveillance System (GLASS) report states, based on 2020 data from 87 countries.

“Antimicrobial resistance undermines modern medicine and puts millions of lives at risk”, said WHO chief Tedros Adhanom Ghebreyesus. 

Tracking resistance

Within the context of national testing coverage, the report, for the first time, analyses antimicrobial resistance (AMR) rates, tracking trends in 27 countries since 2017.

It reveals high levels of bacteria resistance, frequently causing life-threatening bloodstream infections in hospitals, such as Klebsiella pneumoniae and Acinetobacter spp, which require treatment with last-resort antibiotics, such as carbapenems.

However, eight per cent of those infections caused by Klebsiella pneumoniae were resistant to carbapenems, increasing the risk of death.

Drugs rendered ineffective

Bacterial infections are becoming increasingly resistant to treatments, with over 60 per cent of Neisseria gonorrhoea infections, a common sexually transmitted disease, showing resistance to ciprofloxacin, one of the most widely used oral antibacterials.

And over 20 per cent of E.coli isolates, the most common pathogen in urinary tract infections, were resistant to ampicillin and co-trimoxazole, first-line drugs, as well as second-line treatments known as fluoroquinolones.

Deeper dive needed

Although most antimicrobial resistance trends have remained stable over the past four years, bloodstream infections due to resistant E.coli, Salmonella, and gonorrhoea infections, have jumped by at least 15 per cent compared to 2017 rates.

More research is needed to discover why AMR has increased and the extent to which infections are related to hospitalizations and antibiotic treatments during the COVID-19 pandemic.

The pandemic also meant that several countries were unable to report data for 2020.

We must scale up microbiology testing – WHO chief

“To truly understand the extent of the global threat and mount an effective public health response to AMR, we must scale up microbiology testing and provide quality-assured data across all countries, not just wealthier ones”, pressed Tedros.

‘Bug-drug’ combos

New analyses show that countries with lower testing coverage – mostly low and middle-income countries (LMICs) – are more likely to report significantly higher AMR rates for so-called “bug-drug” combinations.

This may be partly because only a limited number of referral hospitals in many LMICs provide data for the GLASS report.

These hospitals often care for the sickest patients who may have received previous antibiotic treatment.

Meanwhile, in terms of antibiotic consumption, 65 per cent of 27 reporting countries met WHO’s target of ensuring that at least 60 per cent of antimicrobials are first or second-line treatments.

These ‘ACCESS’ antibiotics are effective in a wide range of infections with a relatively low risk of creating resistance.

However, insufficient testing coverage and weak laboratory capacity, particularly in LMICs, make AMR rates difficult to interpret.

Moving forward

WHO will follow a two-pronged approach to overcome this critical gap, by gathering short-term evidence through surveys and creating long-term capacity building for routine surveillance.

This will entail national AMR prevalence surveys to generate a baseline of data, and enable tracking trends for policy development, intervention monitoring and increasing quality-assured laboratories to report data throughout all levels of health systems.

Responding to antimicrobial resistance trends requires high country-level commitment to boost surveillance and provide quality data as well as action by all people and communities, said WHO.

By strengthening standardized data collection, the next phase of GLASS will underpin quality data-driven action to stem the emergence and spread of AMR and protect antimicrobial medicines for future generations.

Research